We are a group of scientists & physicians who are working to develop new therapies for lung cancer by harnessing the immune system. Our goal is to co-opt immune mechanisms that distinguish between self and non-self to combat specific subtypes of lung cancer.
The laboratory is located in the Hamon Center for Therapeutic Oncology at the University of Texas Southwestern Medical Center in Dallas, Texas, USA.
Leveraging immunology for lung cancer therapy
Our Research
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Viral mimicry in lung cancer
Disrupting RNA metabolism in cancer cells can trick these cells into thinking that they are infected with a virus. We seek to discover new ways to trigger innate immune pathways in lung cancer cells to “mimic” viral infections and induce cancer cell death.
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Interferon pathway in cancer
Lung cancers can express high levels of interferon-stimulated genes (ISG), which normally function to protect against infections. We aim to identify novel vulnerabilities in lung cancers with high ISG levels, a cell state associated with resistance to cancer immunotherapy.
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T cells in solid tumors
Solid tumors harbor T cells with reactivity against both cancer cells and pathogens. We intend to characterize T cell populations in solid tumors and to use this information to develop new therapeutic approaches to target these tumors, particularly lung cancer.
Contact us!
We are building a team of scientists with varied backgrounds and experiences, including in medicine, cancer biology, RNA biology, bioengineering, immunology, and computational biology. Please consider applying!
Available positions:
Undergraduate researchers
Research technicians
Graduate students
Postdoctoral fellows
Medical students
Medical fellows